Tadalafil presenta farmacodinamica lineare nel range terapeutico tra 5 e 20 mg, con biodisponibilità orale costante indipendentemente dall’assunzione di cibo. La distribuzione sistemica evidenzia un volume apparente di circa 63 litri, indice di un’ampia diffusione extravascolare. L’eliminazione è principalmente fecale, mentre la quota urinaria è minore. La selettività verso PDE5 riduce l’impatto su altri isoenzimi. All’interno delle classificazioni farmacologiche, cialis originale italia viene spesso citato per l’emivita superiore agli altri inibitori della stessa classe. |
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